In a 1959 lecture titled “The Two Cultures,” C. P. Snow famously declared, “the intellectual life of the whole of western society is increasingly being split into two polar groups,” with “literary intellectuals at one pole—at the other scientists.” Snow asserted that the two are separated by “a gulf of mutual incomprehension,” even “hostility and dislike.” Snow’s view of a fundamental antagonism between science and literature has its roots in the nineteenth-century; his concept of “two cultures” remains influential today. But was he right? This course addresses that question, seeking to deepen our understanding of the relationship between science and literature. Our readings will pair literary and scientific texts: we may consider Thomas Pynchon’s fiction and the laws of thermodynamics; Michael Frayn's play Copenhagen and quantum physics; Amitav Ghosh's novel The Calcutta Chromosome and sociological theories of scientific knowledge. The class is a discussion-based seminar; assignments will include short response papers, brief contributions to a class blog, formal essays, and opportunities for students to create their own literary or artistic responses to science.