Science and mathematics in the Renaissance were actively synthesized, theorized, and situated in the material and the visual. Artists and artisans were key both to the production and communication of science, as well as to the pioneering of workshop-based practices and products that influenced the direction of future research and experimentation. This course will survey major intersections of Renaissance art and science, guided by the following questions. How did artistic and visual practices contribute to the development of new forms of scientific knowledge? How did the role of technology enable new modes of visualization? How did the emphasis on experience and observation, central to the artist’s practice, become the basis for natural history and empiricism? What was the role of visuality in the rise of applied mathematics? In considering these questions, we will examine the work of Alberti, Cellini, Dürer, Galileo, Kepler, Leonardo, Palissy, Serlio, and others, and will read them alongside authors on visual theory, including Lenoir, Lynch, Gombrich, Panofksy, and Warburg.